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America is in the affliction of an blubber “epidemic,” but the abundantly alert FDA hasn’t accustomed a new diet bolus in added than a decade. That may change with Orexigen Therapeutics’ admission drug, Contrave, which an FDA console recommended for approval Tuesday. The FDA itself still has to assurance off on the drug, but tends to chase the panel’s recommendations. How does Contrave work, and will it be the argent ammo for America’s weight problem? (Watch a Fox Business altercation about skepticism over Contrave)

What’s Contrave’s secret?It combines two absolute drugs: Bupropion (aka Wellbutrin), the accepted antidepressant and smoking-cessation medication, and naltrexone, acclimated to adverse booze addiction. This aggregate allegedly boosts metabolism while abbreviating appetence to admonition bodies lose weight.

Are the ancillary furnishings bad?Since Contrave contains two accepted drugs, the console absitively the risks are appealing able-bodied understood, and analytic trials advance that the abrogating furnishings of accumulation the two are appealing modest: A slight access in claret burden and pulse, which in approach could accord to affection attacks or strokes. Bupropion can additionally account seizures. The FDA panel, while positive, did acclaim that Orexigen conduct longer, added studies afterwards Contrave is approved.

How able is it?Slightly bigger than the acceptable diet strategy: Eating convalescent and appliance more. The balloon participants waccustomed Contrave agape an boilerplate of 4.2 allotment credibility added off their weight than those demography placebos. That’s beneath than the FDA likes, but the bolus anesthetized aggregation because at atomic 35 percent of Contrave-takers absent 5 percent or added of their weight during the year-long trial. “I anticipate [Orexigen] fabricated it by the beard of their chinny button chin,” says Melanie G. Coffin, the accommodating adumbrative on the panel. “It’s sad to see that that is as far as they could go.”

What added diet pills are out there?The alone decree diet bolus on the U.S. bazaar is the rarely assigned Xenical, which can account alarmist problems, gas, and amoral bowel movements. The absolute U.S. weight-loss biologic bazaar is alone about $382 actor annually, according to IMS Health. If Contrave is accustomed (and is acceptable as able-bodied as expected), it could ability sales of $1.2 billion by 2018, forecasts BioMedTracker. 

Given the blubber crisis, why are there so few pills?The FDA has about accounted diet pills too risky. Merida, one that was accustomed (in 1997), was aloof pulled from the shelves in October afterwards studies showed it added the accident of acclamation and affection attacks. Anti-obesity groups say the FDA has been too cautious, or set the bar too high. “This console has voted adjoin every blubber analysis that has appear afore it this year,” anti-obesity apostle Theodore K. Kyle told the panel. “I ask you

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